In order to mitigate the global warming, development of the technologies for CO2 storage is very necessary. CO2 storage in geological formations especially in deep saline aquifers is considered a promising way. As an important basis, the mechanisms of supercritical CO2 and water two phase flow of in porous media is not yet fully developed. Therefore, to have a better understanding of CO2 migration aquifers, this thesis investigates characteristic functions of multiphase fluid flow migration and the influences of formation heterogeneity and dissolution conditions by using experimental and numerical methods. As important functions of describing multiphase displacement processes in porous media, relative permeability and capillary pressure curves from different core samples are obtained, which provide essential parameters for numerical modeling. This paper also successfully extended relative permeability curves by analyzing capillary pressure experimental data. A 1D modeling approach using multiphase transport code TOUGH2 proposes several set of parameters allowing a good match between experiments and models. Sensitivities of ‘end effect’, capillary pressure, permeability, residual gas and water are analyzed using the same model. A series of experiments are performed to study the influence of the CO2 exsolution, calcite dissolution and precipitation. It shows the effect on permeability due to CO2 exsolution triggered by pressure drop is predictable. Calcite precipitates in different forms depending on chemical conditions, which has a much obvious influence on low permeability rocks than high permeability ones by blocking the pores and/or throats.